PEPTI
19 February 2009Temple research finds an ADHD drug could help individuals with ap
19 February 2009Temple research finds an ADHD drug could help individuals with aphasia regain language abilities.
“The standard of care for patients with aphasia has always been and will always be speech/language therapy, but a new area is opening up that looks at what drugs can be used in combination with therapy to enhance recovery from brain damage and help the brain repair itself,” said Gerry Stefanatos, D.Phil., an associate professor of communication sciences and disorders in the College of Health Professions. “We’re looking at the mechanism of how this combination works — it’s underlying effect on patients with aphasia.”
In research presented at the International Neurological Society this month, Stefanatos found that dextroamphetamine (D-AMPH), a drug commonly used to treat attention deficit hyperactivity disorder, improved the processing of speech among those suffering from Broca’s aphasia and the similar Anomic aphasia.
“Improving a patient’s attention and working memory may allow them to better focus and process information during therapy sessions,” said Stefanatos. “Attention is critically important for learning and relearning skills, and could be helpful in forging new neural pathways in the brain.”
Stefanatos’s research explores the nature and basis of neurogenic language disorders integrate neuropsychological/neurolinguistic approaches to the study of brain function with advanced functional neuroimaging techniques, such as brain electrical source localization and functional magnetic resonance imaging.
Stefanatos’ recent study looked at the use of D-AMPH in ten aphasia patients. All were also given a placebo for comparison purposes. In each condition, participants were asked to make decisions about different types of speech sounds (vowels, consonant-vowels) and complex tones. Their brain’s electrical response to each was recorded via an electroencephalogram (EEG).
Those who took the D-AMPH had a strong reaction to the sounds — even to consonant-vowel sounds, which are more often difficult for individuals with aphasia to process.
“This tells us that D-AMPH may help the left hemisphere of the brain regain the ability to perform its functions,” said Stefanatos. “Understanding why the drug is having this effect allows us to start to think about how to tailor treatments to make them more effective or explore alternative drugs or drug combinations.”
Stefanatos said he and his team chose to look at this particular drug because in patients with ADHD it has been shown to stimulate the release of dopamine and epinephrine, which help in attention and learning. But he notes that some people aren’t good candidates for this particular drug.
“Now that we have a rudimentary understanding of why the drug may work to enhance the results of therapy, our next step is to look at dose effects and perhaps other drugs with more favorable side effect profiles,” said Stefanatos.
With collaborators from the departments of Radiology and Physical Medicine and Rehabilitation, Stefanatos will next study functional magnetic resonance imaging to explore the effects of D-AMPH on cerebral metabolism and where in the brain of individuals with aphasia it has the greatest effect.
Other authors on this study are Andrew DeMarco at Temple University, Robert Segal at McGill University in Quebec, and Arthur Gershoff, M.D. and Y. Ieuji of the Moss Rehab Stroke and Neurological Diseases Program, part of the Albert Einstein Healthcare Network in Philadelphia. This work was funded by grants from the National Institute of Health and the Pennsylvania Department of Health.
Stefanatos has written numerous articles published in scientific journals and has authored several chapters in textbooks in the field of neuropsychology and cognitive neuroscience. These have covered conditions such as attention deficit hyperactivity disorder, autism, Asperger’s disorder, developmental language disorder, and aphasia. His editorial responsibilities have included reviewing research papers for “Brain and Development, “Brain and Cognition, Neuropsychologia, Biological Psychiatry, Child Neuropsychology, Journal of Child Psychology and Psychiatry, the Journal of Developmental and Learning Disorders, Neuropsychiatric Genetics, Neurocase, Clinical Neuropsychologist, and Journal of Neuropsychological Rehabilitation. He has also served on scientific review committees for the National Institute of Health.
Stefanatos has received funding from the National Institute on Deafness and Communicative Disorders, the National Institute of Child Health and Development, the Pennsylvania Department of Health and the Albert Einstein Society.
Marie Bernard
18 February 2009Marie Bernard to Speak at Women’s Health Research Symposium at Temple March 26
David Post
18 February 2009Human Smoke
29 May 2008
Nicholson Baker’s book Human Smoke: The Beginnings of World War II, the End of Civilization (Simon & Schuster, 2008) has gotten very bad press.
The angry reviews are defensive. Anne Applebaum in The New Republic writes
“And the reader, both of The Da Vinci Code and Human Smoke, is duly flattered. Read Brown’s book and you, all by yourself, can decide whether Jesus was married to Mary Magdalene! Read Baker’s book and you, all by yourself, can decide whether World War II was worth fighting! You too can get the facts and make up your mind! And never mind that the facts have been chosen selectively, even randomly, by writers who do not understand the context in which they originally appeared, and indeed have deliberately tried not to understand it. Brown and Baker are not “experts,” after all. They are, to put it politely, artistes.”
I really don’t understand the cult of the expert any more than I do the newer cult of the amateur. But as a college graduate, I am offended by the notion that I am not qualified to decide all by myself, if the Second World War was good or Jesus was married. The latter question is meaningless, but the moral status of war, and of any particular war, is something about which every American voter should have an opinion. An informed opinion.
Nicholson Baker didn’t supply me with my opinion, but he did inform. Thanks.
You need a communications consultant…
29 May 2008You need a communications consultant…
..because you’re a smart person running a worthy organization, and yet, the world either ignores or misunderstands what you do. If you don’t create and maintain your own image, someone else will. That may be an individual or a group with a different, or even an opposing mission. A mission-driven organization has a responsibility to make its mission understood. You may be trying to reach a number of different audiences—some sympathetic, some hostile, all skeptical.
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Your task is to communicate with all of them.
What can a communications consultant do for you?
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What kinds of writing can you expect from Paul Statt Communications?
· Research
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Paul S. Statt is a senior communications officer, advisor, and journalist with a 15-year record of accomplishment in the development, implementation, and maintenance of integrated communications products. A skilled writer and researcher with experience in higher education, online and print media, and information technology, Statt can offer
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Seeing in the Blind Spot
6 December 2007Every driver knows—or should know—about the “blind spot,” that part of the road that you just can’t see in any of your car’s rear-view mirrors, the spot that all too often hides a semi-tractor trailer full of hazardous wastes passing you at 70 miles an hour on a crowded turnpike.
R. Andrew Hicks, an associate professor of mathematics at Drexel University, has a better solution than a quick turn of the head and a yelp of surprise. He has created a slightly and elegantly curved mirror that provides drivers with a 45 degree field of view on the driver’s side. A flat mirror provides less than 20 degrees. The difference is dramatic.
Flat mirrors do not provide a wide enough field of view. Trucks and buses make use of spherical mirrors, which broaden the field, but increase the distortion of the image. The passenger-side mirror on a car, the one with the worrisome note that “objects in the mirror may be closer than they appear,” also trades a wider field for a distorted view.
Hicks has been working on creating very wide fields of view, in the new field of “omnidirectional vision,” sometimes also called panoramic vision, which has been developed to help robots to “see.” A mobile robot might use a camera with an extremely wide-angle “fish-eye” lens or with curved mirrors mounted in front of a standard lens. Omnidirectional vision provides a very large field of view.
Curved mirrors can provide the same kind of panoramic views—such as often seen in CCTV security cameras. Hicks was designing such mirrors for robots as a postdoctoral fellow at the General Robotics, Automation, Sensing, and Perception Laboratory at the University of Pennsylvania, where he received a Ph.D. in mathematics in 1995. He also was learning a lot about the problems of building them. The theoretical design of a curved mirror that has a wide and undistorted view is a “problem of classical optics,” Hicks says. That elegantly drawn curve, however, was until recently impossible to translate into a physical mirror. “The tricky part is that the machines that could actually build a practical design didn’t exist before 2000. So nobody really explored making such a mirror.”
Hicks can now make and demonstrate such a mirror, but he can’t sell it: U.S. law prohibits a curved mirror on the driver’s side. (It is allowed in Europe and Japan and as an add-on in the U.S.) Until that can be changed, he still advocates, as your driver-ed teacher did, an occasional quick glance over the shoulder.
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18th-Century Architecture: 21st-Century Technology
5 December 2007
All the students in the Digital Media Program at the Antoinette Westphal College of Media Arts and Design learn how to create the latest in computer graphics and animations. But the students working at Independence National Historical Park with Glen Muschio, the director of the program, are also getting a crash course in American history. Philadelphia may be America’s most historic city, but much of what the tourist sees has been reconstructed over the centuries. Drexel University researchers are beginning to uncover what 18th-century Philadelphia was really like—and to create an interactive computer model of it that anyone can explore. Muschio, Chris Redmann, assistant professor of digital media and their students have been recreating exact 3-D replicas of colonial-era structures. The project brings together faculty and students from the computer science department in the College of Engineering, the culture and communication department in the College of Arts and Sciences, the College of Information Science and Technology and the School of Education.
The collaborative 3-D Colonial Philadelphia
will serve as a research and production center for models, animations and interactive media—a repository for “virtual artifacts” of colonial life, in searchable databases for researchers and scholars. The Dexter House was recreated based on information regarding the house foundation obtained at the site and a survey of buildings from the time period fitting the style of the house and buildings created by the Dexter House’s carpenter.
“We want this to be a resource for research, production, use and evaluation of digital assets for studying U.S. history,” says Muschio. The project is part Second Life, part social history, part SimCity, part computer science and part teaching tool. “What we hope to do is create a 3-D environment for teaching and learning about colonial American history in schools, at historic sites and on the Web” he adds.
One of the first homes recreated in their virtual 18th-century Philadelphia is a two-story brick house located in the vicinity of Fifth and Arch Streets that belonged to James Oronoko Dexter, a prominent and free African-American. Dexter is believed to have held meetings at his house for the creation of the first independent African American church. The original house was demolished in the 19th century, but recent archeological digs brought to light information about the house and site.
Muschio and his students have built the exterior and interior spaces of the home with historical accuracy and will scan artifacts found from the dig to restore the interior to its 18th– century look. Another building, the Whitall House, home of wealthy Quakers, which still stands in Woodbury, N.J. opposite Philadelphia International Airport, has been another model.
The future of the project includes regional sites and events that were historically significant to the development of the city’s culture and economics. “3-D Colonial Philadelphia will evolve as technology advances and as we too develop cutting- edge technology to move the field forward,” says Muschio. He wants to recreate the 18th-century city and its economic ecosystem, eventually populating its buildings with digitized characters, or avatars, who will show visitors the objects found there, and tell them about the significance of the site—like virtual tour guides. “As AI [artificial intelligence] capabilities develop, we hope that the interaction will get to the state where we can really do this on a big scale and people can get involved in role-playing games. That’s where we’re headed. Right now, were building the spaces in a photo-realistic way.”
“We are working with the computer science department, which is interested in creating algorithms that will allow them to work with the National Park Service to virtually reconstruct the Dexter artifacts, based on the remnants that were uncovered,” said Muschio. “We’re also working with information-science technology to create databases so we can get a handle on all of this stuff, because we hope to make this available to other researchers in other cities who might not have the types of resources we have in terms of window types, brick face, things like that.”
Chris Redmann, an architect and 3-D animator with an interest in historic preservation, is directing the construction of the 3-D virtual environments. He’s teaching his undergraduate and graduate students to use the Historic American Building Survey (HABS) and the Historic American Engineering Record (HAER) as guides for reconstructing 3-D models of historic buildings. These digital assets will be used to construct virtual period buildings that are known to have stood on specific plots, but are undocumented in terms of detailed descriptions. The faculty and students will also research insurance, tax and deed records noting physical descriptions and positioning of structures.
The resulting database of colonial Philadelphia doors, windows, brick faces and other common features could be dropped into a scene or a row of houses quickly. Whole blocks, which might have sketchy historical records at best, could then be recreated with some measure of authenticity.
Working from HABS blueprints, undergraduate student Brian Gadomski, has already built an archive of 18th-century house doors and windows. “I’m bringing them into 3-D and I’m tracing them in the computer, and building, based on the original drawing, a geometry that matches exactly with those,” he says. “It’s a process that’s relatively simple but will allow us to create a data base of doors and windows that can be used eventually in the complete Colonial Philadelphia.”
“Using this method, it will not be possible to know what every specific house in the city looked like,” said Muschio. “Detailed treatments will be reserved for historically significant structures that are well documented.”
“I actually learned a lot about the Dexter house while doing it,” said Chester Cunanan, a graduate student in digital media. “How they had the first meetings there that eventually led to the first African American church in Philadelphia and how the Quakers worked with that.”Cunanan says that he has learned more than he expected. “You have to learn about the history of the place to build the place properly, and then the history catches you at that point. So when it starts, maybe you weren’t totally into the history, but when it ends, you’re not only interested in the place, but the history and the place. The history pushes you on—it’s the impetus that drives you after the fun of playing with a new toy wears off.”
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The Mysteries of Autism
30 November 2007
The definition of an epidemic is simple, but subjective, warns Craig Newschaffer, professor and chairman of the department of epidemiology and biostatistics at the Drexel University School of Public Health: “An epidemic means that there are more cases of a disease than we would expect.” He cites the example of smallpox, an affliction for which a single confirmed case would qualify as an epidemic, because the disease has been eliminated in humans. On the other hand, when everybody you know has a cold, that’s to be expected, and therefore not an epidemic.
What about autism? In the last 20 years the number of reported cases has gone up—everyone agrees. But has autism increased more than expected? Are we in the midst of an autism epidemic?
It’s hard to tell, for many reasons, and Newschaffer, to the dismay of many a reporter looking for a sound bite that answers the question, knows them all. “”For one thing,” Newschaffer notes, “autism isn’t one thing. It’s a spectrum of disorders.” That means different and perhaps unknown causes, risk factors, and genetic predispositions.
Might the increase in autism be due to improved diagnostics, that is, to children who would previously have been diagnosed with mental retardation or learning disabilities today being diagnosed with autism? Experts debate the issue. Parents worry that there’s “something out there” causing autism.
“There are two major hypotheses,” Newschaffer says. “One is that something is going on that increases children’s risk of autism. The other is that the increased number of cases is due to changes in the autism diagnosis and an increased tendency to diagnose autism instead of something else.”
What causes autism? “Like cancer, autism is a very complex disease,” says Newschaffer, “and it’s exciting to start asking questions about the interaction between genes and environment. There’s really a very rich array of potential exposure variables.”
Newschaffer says we don’t know the cause of autism. That means autism diagnosis has to be made on the basis of behavior rather than biology—and that’s the always unpredictable behavior of a child we’re looking at. And studies that look back at the infant behavior of older children, before the disease was well-known, simply aren’t a sharp enough tool to unearth, once and for all, whether autism was as common in the past as it is now.
There strong beliefs on both the “nature” and “nurture” sides of the issue,” Newschaffer says. “But if you try to get objective and sit back –if you try to be honest –I don’t think the data are valid, precise, or good enough to tease these things out.” But “we need to consider environmental risk factors.”
Many new studies are in progress. But Newschaffer doubts that a definitive answer will be found soon. “We are not likely to develop a conclusive body of evidence to either fully support or fully refute the notion that there has been some real increase in autism risk over the past two decades,” he says.
In a 2005 study, Newschaffer and his colleagues concluded that shifting diagnostic categories alone can’t account for the increase in autism cases. Newschaffer’s data suggested some increase in autism cases. “Saying that it’s an epidemic is a powerful word,” he reminds us—it means more public attention and funding.
After the release of data from the Centers for Disease Control and Prevention (CDC) on autism prevalence in the spring of 2007, Newschaffer was invited to speak to the Congressional Caucus on Autism Research and Education to offer his expert opinion on the new data from the CDC autism and developmental disabilities monitoring (ADDM) project. The project indicates that almost seven in 1,000 8-year-old children had an autism spectrum disorder. The data, collected across multiple project sites nationwide, represents the best available estimate of the prevalence of autism in the United States. Fourteen ADDM project sites are established across the nation, including sites in Pennsylvania, New Jersey and Maryland. Newschaffer, who joined the faculty of the School of Public Health this past fall, was one of the first ADDM project principal investigators and remains affiliated with the Maryland ADDM project site.
Newschaffer stresses the importance of identifying common symptoms within the wide variety of autism spectrum disorders, as well as ways to better observe genes and the environment together. He also notes that several federally funded epidemiological studies are underway to pinpoint possible environmental triggers for autism, including an initiative by the CDC. Newschaffer serves as co-principal investigator of this CDC study, which is expected to review 2,700 children over the next five years.
He’s working on an interesting new study, working at Drexel’s 11th Street Clinic with mothers of autistic children—a “high-risk cohort—”who are now pregnant again. “The benefit of early identification is immeasurable,” he says, although he does “hope to measure it.” “We need to get the word out to families.” He says that starting out at birth with a child at risk of autism offers the best hope that he might find the biomarkers for autism. “The richest samples” for biomarkers, he says, are in the placenta. “What genes are expressed by the baby in the womb?” he asks. The whole first year of the project, the year he’s in now, calls for recruitment and outreach. “We’re not rushing into data collection,” he notes. “If you don’t have a lot of data, you’re not doing science.”This is not treatment research.”
The ultimate goal for Newschaffer and his colleagues is a comprehensive collection of all the available about the disease: the National Database for Autism Research NDAR (http://ndar.nih.gov/ ) “Adding to some body of knowledge: that’s the goal. We’re in public health,” Newschaffer says, “to prevent mobility and mortality from diseases. A “cure” is really tertiary prevention—in public health we’re really into primary prevention: stopping disease before it happens.”
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Professor and chairman of the department of epidemiology and biostatistics at the Drexel University School of Public Health, Newschaffer was recently at the department of epidemiology at the Johns Hopkins Bloomberg School of Public Health. At Johns Hopkins, Newschaffer founded and directed the Center for Autism and Developmental Disabilities Epidemiology, one of five federally funded centers of excellence in autism epidemiology. Major initiatives included the development of methods for monitoring autism spectrum disorders prevalence and participation in the largest population-based epidemiologic study of autism risk factors to date – the National CADDRE Study of Autism and Child Development. Dr. Newschaffer also is engaged in other projects focusing on how particular genes might interact with environment exposures to increase autism risk. His recently began a collaboration with Peking University to explore approaches for conducting epidemiologic research on autism in China. Newschaffer is an Associate Editor of the American Journal of Epidemiology, and a member of the editorial board of the journal, Developmental Epidemiology.
The Badger Game: Colored Amazons
25 November 2007African-American women make up about a half of the women incarcerated in the United States, and are the fastest growing population in today’s jails and prisons.
Kali N. Gross, an assistant professor of history and the director of the Africana Studies Program in the College of Arts and Sciences, knows that the problem isn’t new: its long and troubling history offers insight into the volatile mix of race and gender in American society. She has been studying the history of the crimes and imprisonment of black women in Philadelphia after the Civil War and recently published Colored Amazons: Crime, Violence, and Black Women in the City of Brotherly Love, 1880-1910 (Duke University Press, 2006).
Gross reconstructs the crimes committed by, and attributed to, black women, as well as their portrayal in the popular press and in the pamphlets and speeches of urban and penal reformers. She considers what these crimes signified about the experiences, ambitions and frustrations of these marginalized women. The perpetrators and the state, Gross argues, jointly constructed black female crime. For some women, crime functioned as a means to attain personal and social autonomy. For the state, black female crime justified a host of urban reform initiatives that reaffirmed white, middle-class authority.
Providing an overview of Philadelphia’s incarcerated black women, she also describes their work, housing and leisure activities and their social position in relation to the city’s native-born whites, European immigrants, and elite and middle-class African Americans. She relates how news accounts exaggerated black female crime, trading in sensationalistic portraits of threatening “colored Amazons,” and she considers criminologists’ interpretations of the women’s criminal acts, interpretations largely based on racist notions of hereditary criminality. Gross contends that the history of black female criminals is in many ways a history of the rift between the political rhetoric of democracy and the legal and social realities of those marginalized by its failures.
To write the history of black women criminals at the end of the 19th century, Gross had to grapple with problematic and challenging primary sources. When black women appeared in the pages of the Philadelphia newspapers, the eroticized horror stories of “Black Amazons” on the rampage offered titillation for contemporary readers. These accounts provide Gross today with a historical record that reveals much about the racism of the courts and the press of the times, but little about the people themselves. And yet: “If they didn’t have criminal records these women wouldn’t show up at all” in the historical record, Gross says.
The historian’s work is to interpret such difficult data. Gross’s research methods involved painstaking close reading of an astonishing array of materials: Statistics, scandal rags, prison records, official trial transcripts, news accounts, and occasional mug-shots are the raw material of Gross’s research. Her work is especially persuasive because she has the statistics to demonstrate racist court practices. The numbers of black people in prison far outweighed their numbers in Philadelphia, and black women faced the most discrimination, evident in the large number of them incarcerated.
In addition to statistics, Gross says her narrative reveals the ways in which “criminal acts and courtroom and prison behavior were also expressive acts—they were texts to be read,” for a deeper understanding of the women’s motivations and their social context. “I use the criminal records and the crimes themselves as texts,” she says. “Badger theft,” as Gross reads it, “is a crime that speaks volumes about frustration and rage.” “The badger game” was a trick that an enterprising black woman might employ against a white man: she would lure him into an out-of-the-way nook with a promise of prostitution, and then rob him before the act. Most often, the shame of having solicited a black woman prevented the victim from pressing charges. If he did, he would be the butt of ridicule in court. Gross infers that many cases of this crime must therefore have gone unrecorded.
It was a dangerous game. The risk of death was always present, as it was in the lives of all black men and women of Philadelphia at that time. The crimes she describes are often shockingly violent; Gross wanted to know, “How did these women learn to be so violent?” Black Philadelphia was a place where crime was often a way for the powerless to assert some control over their lives—Gross refers to a “tropic of violence.” Black women not only reflected a violent environment, they often had to turn to violent crime to establish any agency in a racist and sexist society. But she resists turning them into romanticized rebels.
In the course of her research, Gross learned to appreciate the efforts of these black women to take some place in a society that excluded them. One accused thief wrote a letter to the court—a rare case where we have the actual words of a black woman,” says Gross—that she was “trying to enjoy the rights of my citizenship.” Many of these women were freed slaves or the children of slaves. Gross says that when she had completed her research, she “was actually shocked that there wasn’t more crime.”
While noted for its Quaker tolerance, “Philadelphia had its own brand of racism,” Gross says. She demonstrates the obvious difference in tone in two accounts of the same crime in two Philadelphia newspapers, one of which thought the assailant was black, the other white. Was the weapon, as the Inquirer reported, “a large pocket-knife,” “plunged into the back” ? Or was it a “small knife that she happened to have in her hands,” as the Times-Philadelphia reporter, who thought she was white, wrote?
She spent hours poring over crumbling newspapers, fading photographs and dry prison records but Gross recalls that her scholarly exploration of black women in prison didn’t begin in any dusty archive. “This book began behind bars,” she says, “when I team-taught a seminar to female inmates at the State Correctional Institution in Muncy, Pennsylvania in 1999,” while she was working on Ph.D. in history at the University of Pennsylvania. “I wanted to us my expertise as a historian to educate and empower these women,” but she found that was “telling uplifting tales of noble suffering and perseverance—themes that dominate much of African-American history—to women who, by those accounts, would be thought failures.”Colored Amazons was a way to tell their story. Gross is unequivocal about why she does it. “The subject of black female criminality merits much more scholarly attention—from historians and politicians too.”
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Gross has an extensive background in the study of race and crime and also in the experience of blacks in the U.S., the Caribbean, and in South America. She received a B.A. degree in Africana Studies from Cornell University and an M.A. and Ph.D. in American Civilization and History from the University of Pennsylvania and has been the recipient of numerous awards and fellowships, some of the most notable being a Ford Postdoctoral Fellowship hosted at Princeton University, a postdoctoral fellowship at the Schomburg Center for Research in Black Culture in New York City, and the Letitia Woods Brown Memorial Prize, presented by the Association of Black Women Historians.
Posted by Paul Statt